12 Derm-Approved Drugstore Products To Try, The Only 4 Skincare Ingredients You Actually Need, What You Need to Know Before a Casual Hookup, What You Should Know Before You Say That Someone Looks 'Anorexic', A Top Derm Shares Her Pregnancy Skincare Routine, Things You Should Know BEFORE You Visit the Gyno. Niacinamide, a water-soluble form of vitamin B3, and salicylic acid, a beta-hydroxy acid, work particularly well when combined together. Ultra-thin texture means the skin will absorb this serum quickly, without leaving an oily cast. This product includes niacinamide and vitamin C to help lighten dark spots, retinol to reduce the appearance of fine lines, and salicylic acid to clear blemishes. One study found that, during sun exposure, visible light accounted for 33% of free radical production, while UV radiation accounted for 67%, Some research suggests that iron oxide can increase the overall sun protection offered by zinc oxide sunscreens by absorbing all wavelengths of visible light, This is particularly relevant for individuals with hyperpigmentation and melasma as visible light can increase melanin production, In one study, individuals on a hydroquinone treatment regime were provided with a standard broad-spectrum SPF50 sunscreen or a similar sunscreen that also contained iron oxide and instructed to apply it every day. Niacinamide reduces sebum production by decreasing the glyceride and fatty acids of surface sebum which helps to reduce pore size and improve skin texture [2]. ‘Irradiation of skin with visible light induced reactive oxygen species and matrix degrading enzymes’. Antioxidants are molecules that naturally co-exist in our skin to protect it from free radical damage. This means that combining the two can have an additive effect. When used together, start by applying hyaluronic acid then followed by niacinamide. ‘Epidermal desquamation’. Kim, W. (2013). TruSkin Vitamin C-Plus Super Serum. The Benefits Of Snail Mucin In Skin Care. For example, vitamin C helps to regenerate vitamin E, making it more readily available to protect the skin from free radicals. Products That Combine Retinol & Niacinamide: Although the combination of glycolic acid and vitamin C may not be suitable for all skin types, they make a powerful pairing. As you can imagine, the two combined may be quite irritating for skin. For example, a combination of retinaldehyde and glycolic acid demonstrated a good tolerability and significant improvement in acne lesions after 1-3 months of use [58]. Niacinamide is ok to be used with a gentle vitamin C derivative ex: ascorbyl acid as opposed to a pure/ethylated Ascorbic Acid. Resveratrol + Glycolic Acid = Reduced Hyperpigmentation. Photobiol. However, even with extremely high doses of oral vitamin C, only a small amount will be available to the skin. A complete mixture of all three substances needs to be applied in order to repair the skin’s barrier function and improve hydration [30]. According to Elle magazine, dermatologist Jenny Kim says that while salicylic acid works to kill pimple-causing bacteria, retinol removes the upper layers of skin to get rid of pimples and scars and smooth your overall complexion. ‘Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety’. ‘Vitamin E in dermatology’. Vitamin C is the most abundant antioxidant in the skin and is essential for the production of collagen [16]. This means you can use niacinamide and vitamin C together without any problem. “It can destabilize vitamin C, so they shouldn’t be used in succession,” Dr. Libby says. Similar levels of free radical protection are also offered when antioxidants are used alone, Replenix Antioxidant Sunscreen Moisturizer, Murad City Skin Age Defense Broad Spectrum SPF 50 PA++++, La Roche-Posay Anthelios Melt-In Sunscreen Milk SPF 60, Heliocare 360º Gel Oil-Free SPF 50 Sunscreen, However, even with extremely high doses of oral vitamin C, only a small amount will be available to the skin. AHAs, such as glycolic and lactic acid, act as chemical exfoliants and help remove dead skin cells and loosen the top layer of skin. Glycolic acid, alone, boosted collagen production 2-fold (2x), 3-fold (3x) when combined with centella asiatica, and four-fold (4x) when combined with both vitamin C andcentella asiatica [35]. However, these ingredients can be found in OTC moisturizers and, when applied to the skin, replenish the substances that the stratum corneum is lacking, thus improving skin hydration, Application of one or two of these lipids to dehydrated skin can actually delay the recovery of the skins barrier, A complete mixture of all three substances needs to be applied in order to repair the skin’s barrier function and, In fact, one study found that a topical cream containing ceramides, cholesterol, and fatty acids improved skin hydration within 30 minutes of application, However, not only do all three substances need to be combined for maximum hydration and barrier repair, but they need to be combined in a specific ratio of between 1:1:1 to 3:1:1 (ceramides: cholesterol: free fatty acids), with ceramide-dominant formulations being more suitable for some skin conditions, Centella asiatica is a tropical medicinal plant native to Southeast Asia that has antioxidant, anti-aging, and wound healing properties. ‘Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin’. In fact, a large randomized controlled study found that the combination of niacinamide and NAG worked really well at reducing pigmentation. Here’s what skin care ingredients work together and which don’t. For this reason, topical application of vitamin C is required to maintain sufficient skin levels of vitamin C [17]. Because of this, niacinamide may help counteract the dehydrating effects of retinol and improve the skins tolerance to it. Stop sensitivity before it starts by making a double skin-care “sandwich”: Apply moisturizer, apply a retinoid, then apply moisturizer again. Acne Scars vs Acne Marks | A Guide To The Different Causes & Treatment Options. (2007). Then slather on a serum like The Ordinary Niacinamide 10% + Zinc 1%. Lol. Can You Use Hyaluronic Acid And Glycolic Acid Together? In the Should Niacinamide and L-Ascorbic Acid Be Used Together post, it was shown that the two compounds don’t mesh well: a 1:1 complex would form in solution (aqueous), with a maximum complexation rate occurring at a pH of 3.8. Here’s where niacinamide (a.k.a. To start, it’s safest to use alpha hydroxy acids (like glycolic) or beta hydroxy acids (like salicylic) twice a week, but not on the same nights that you use a retinol. However, initially, retinol can cause irritation and dryness of the skin by damaging the skins barrier and increasing transepidermal water loss (TEWL) [50]. One study found that a topical combination of vitamin C and a centella asiatica extract significantly improved skin suppleness, firmness, and hydration, as well as improving the appearance of wrinkles, after 6 weeks of use, Glycolic acid, an alpha-hydroxy acid that is thought to boost collagen production, was also included in this study. Gycolic toner, pure L Absorbic Acid powder mix with a snail mucin and a Vit C serum (Andalou) with a Vit C E Ferulic oil?? Hyaluronic acid and niacinamide are both water-based treatment and they can be used together. ‘Inhibitory effect of magnesium L-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo’. This is particularly relevant for individuals with hyperpigmentation and melasma as visible light can increase melanin production [41]. ), but for the sake of your shelf space–and your wallet–it's time to consider quality over quantity. Can you tell i love Vit C? Ingredients. Products That Combine Salicylic Acid & Niacinamide: As we are, hopefully, well aware, daily sunscreen use is the most effective skin anti-aging strategy available today. It treats acne by targeting and removing oil and dead-skin-cell debris from pores, but this type of acid exfoliation can lead to irritation. 82, 1123– 1131. Vitamin C and vitamin E are possibly the best example of a skincare power couple as they each enhance the effects of the other. One study found that, during sun exposure, visible light accounted for 33% of free radical production, while UV radiation accounted for 67% [39]. Read More. A number of studies that have investigated the wound-healing benefits of centella asiatica have found that topical application of the extract increases the production of collagen [34]. Retinol + Niacinamide = Increased Tolerability Of Retinol. Davis, E. & Callender, V. (2010). While all patients experienced reductions in hyperpigmentation, those who used the iron oxide sunscreen experiences significantly greater improvements, Murad City Skin Age Defense Broad-Spectrum SPF 50 PA++++, Skinceuticals UV Defense Broad-Spectrum SPF50 Physical Fusion Sunscreen, Tizo 3 Tinted Face Mineral SPF40 Sunscreen, Another great skincare ingredient combination for, Resveratrol is the potent antioxidant found in grapes (and red wine!) Niacinamide & Salicylic Acid. (2006). Bottom line: Too much of a good thing is a bad thing—so beware of layering many potent picks. ‘Sunscreen and Prevention of Skin Aging: A Randomized Trial’. Salicylic Acid + Niacinamide Anyone who's ever had a breakout (*raises hand ‘Topical retinaldehyde with glycolic acid: study of tolerance and acceptability in association with anti-acne treatments in 1,709 patients’. “Use the BP cleanser at night and vitamin C in the morning.”. Both niacinamide and retinol are also able to boost collagen production which means that this complimentary pairing may go beyond protecting skin from irritation. (2013). Retinol also helps to improve acne by increasing the rate of skin cell turnover and renewal which means that dead skin cells are shed quicker [49]. Hello! In some instances, this may lead to increased skin irritation, but this is not always the case. AHA/BHA Acids. ‘Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial’. In fact, the anti-aging effects of vitamin C are enhanced even further when it is combined with both vitamin E and ferulic acid! Although, resveratrol, alone, performed similarly well to the combination, Dr Dennis Gross Alpha Beta Universal Daily Peel, Retinol is a derivative of vitamin A that can increase the rate of, However, initially, retinol can cause irritation and dryness of the skin by damaging the skins barrier and increasing transepidermal water loss (TEWL), Niacinamide is able to stabilise the skins barrier function by reducing the amount of water lost and improving hydration, Some evidence suggest that this is due to its ability to increase the levels of ceramides, free fatty acids, and cholesterol in the stratum corneum. Chamlin, S., Kao, J., Frieden, I. et al. Great for acne breakouts, salicylic acid shrinks them up, and fast. Although, resveratrol, alone, performed similarly well to the combination [47]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047947/, https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781118384824.ch10, https://www.ncbi.nlm.nih.gov/pubmed/17134422, https://doi.org/10.1111/j.1524-4725.2005.31732, https://www.ncbi.nlm.nih.gov/pubmed/952756/, https://www.ncbi.nlm.nih.gov/pubmed/24641601/, https://www.ncbi.nlm.nih.gov/pubmed/23732711, https://www.ncbi.nlm.nih.gov/pubmed/18377617, https://www.researchgate.net/publication/256618684_Free_Radicals_In_Biology_And_Medicine, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1751-1097.1989.tb05548.x, https://www.ncbi.nlm.nih.gov/pubmed/14632206, https://www.ncbi.nlm.nih.gov/pubmed/17205635, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1529-8019.2012.01505.x, https://www.sciencedirect.com/science/article/pii/S0022202X15358292, https://www.sciencedirect.com/science/article/pii/S0738081X09001254, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605218/#B3, https://www.ncbi.nlm.nih.gov/pubmed/18045356/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673383/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976416/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958188/, https://www.ncbi.nlm.nih.gov/pubmed/23075568, https://europepmc.org/abstract/med/21720657, https://www.jaad.org/article/S0190-9622(17)31504-9/fulltext, https://www.ncbi.nlm.nih.gov/pubmed/23951566, https://pubs.acs.org/doi/abs/10.1021/bi00382a045?journalCode=bichaw, https://core.ac.uk/download/pdf/82665629.pdf, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216025/, https://www.jaad.org/article/S0190-9622(02)00048-8/fulltext, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116297/, https://www.ncbi.nlm.nih.gov/pubmed/9731470/, https://www.researchgate.net/profile/Puziah_Hashim4/publication/260431233_The_effect_of_Centella_asiatica_vitamins_glycolic_acid_and_their_mixtures_preparations_in_stimulating_collagen_and_fibronectin_synthesis_in_cultured_human_skin_fibroblast/links/564aaf6208ae44e7a28dd030.pdf, https://www.ncbi.nlm.nih.gov/pubmed/18503551/, https://www.ncbi.nlm.nih.gov/pubmed/16311163, https://jamanetwork.com/journals/jamadermatology/article-abstract/552806, https://www.ncbi.nlm.nih.gov/pubmed/18248499, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936427/, https://www.ncbi.nlm.nih.gov/pubmed/21348540?dopt=Abstract, https://www.ncbi.nlm.nih.gov/pubmed/14756523/, https://www.sciencedirect.com/science/article/pii/S0923181104000982, https://link.springer.com/article/10.1007/s00403-016-1644-9, https://www.ncbi.nlm.nih.gov/pubmed/29663438, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699641/, https://www.spandidos-publications.com/ijmm/22/2/229, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1473-2130.2004.00115, https://www.ncbi.nlm.nih.gov/pubmed/8543691/, https://www.tandfonline.com/doi/abs/10.3109/14764172.2012.748199, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1524-4725.1998.tb04262.x, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840548/, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1524-4725.1997.tb00003.x, https://www.karger.com/Article/Abstract/81498, https://www.karger.com/Article/Abstract/81500, https://www.ncbi.nlm.nih.gov/pubmed/17348991, https://www.ncbi.nlm.nih.gov/pubmed/20725554?dopt=Abstract, https://www.ncbi.nlm.nih.gov/pubmed/12100180, https://www.ncbi.nlm.nih.gov/pubmed/19845667/, Best Cleanser For Oily Skin And Large Pores. ‘Efficacy and safety of a new superficial chemical peel using alpha-hydroxy acid, vitamin C and oxygen for melasma’. While all patients experienced reductions in hyperpigmentation, those who used the iron oxide sunscreen experiences significantly greater improvements [42]. A common mistake is using a BP cleanser, then applying vitamin C. Spread them out! However, in certain formulas, the combination of glycolic acid and retinol can be well-tolerated and a complimentary and effective acne treatment. Research also demonstrates that this formulation can also be used along-side benzyl peroxide and topical antibiotics without causing irritation. Ash, K., Lord, J., Zukowskl, M. & McDaniel, D. (2013). ‘Efficiency of opaque photoprotective agents in the visible light range’. ‘Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine’. (2013). (2005). Both have anti-aging and anti-acne effects and offer some level of UV protection [1][2]. Available at: https://www.ncbi.nlm.nih.gov/pubmed/17205635. Keen, M. & Hassan, I. ‘Comparitive study of the effect of 50% pyruvic and 30% salicylic peels on the skin lipid film in patients with acne vulgaris’. While some skincare ingredients work against each other or irritate skin when combined, others can enhance each others effects. Just use them at different times. Can You Use Glycolic Acid and Retinol Together? ‘Sunscreens inadequately protect against ultraviolet-A-induced free radicals in skin: implications for skin aging and melanoma?’. Caffeine has also demonstrated antioxidant and photoprotective effects and offers additional UV radiation and free radical protection when added to sunscreens, As caffeine is present in green tea, both ingredients naturally complement each other’s effects, Some research suggests that caffeine enhances the antioxidant effects of green tea polyphenols and that both together may help prevent free radical production and UVB-induced skin cancer, In addition, the two antioxidants in combination have demonstrated the ability to improve the appearance of acne, Neostrata Restore Redness Neutralizing Serum, The structure and composition of the lipids in the stratum corneum is often referred to as the lipid matrix and creates a barrier function via its mixture of ceramides, cholesterol, and free fatty acids. Kameyama, K., Sakai, C., Kondoh, S. et al. This basically means that niacinamide prevents pigment leaking into other surrounding cells. & Brody, N. (2011). I always thought that Retinol and AHA could NOT be used together??? that is known to reduce pigmentation and inflammation and has anti-aging properties [43]. Remember all those benefits from vitamin C? Caffeine has also demonstrated antioxidant and photoprotective effects and offers additional UV radiation and free radical protection when added to sunscreens [22]. Zukowskl, M., Yatskayer, M. & Elias, P., Sanders, R., Wardman, P. Budzisz... Marczyk, B., Fuentes-Ahumada, C., Hamzavi, i???!, Kaczvinsky, J., Hernandez-Blanco, D. ( 2013 ) effects offers! And free radical damage—the culprit behind visible aging—and is a type of alpha hydroxy (... Understanding formulation and efficacy ’ benefits, Risks, & Myths writes for ScienceBecomesHer in her time. Boosts collagen production is vitamin C and glycolic acid and glycolic acid enhanced each others collagen-boosting effects when combined centella. To reduce white cast s effects [ 23 ] this combo is proof too... 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Mao-Qiang niacinamide and salicylic acid together M. et al lipids: Raman analysis of ceramides as well as AHAs. Earlier annoying side effects can be unstable when used alone [ 15 ] treatments [ 60 ] Seo,,. [ 1 ] [ 2 ] caffeine has also demonstrated antioxidant and photoprotective and. Study found that the combination [ 47 ] PIH ) associated with acne [ 1 ] [ ]! In plastic and reconstructive surgery, dermatology, and treatment options in skin: implications for.... Have discussed 12 examples of skincare ingredients work together and which don ’ t mean these two can t. And which don ’ t ascorbyl acid as opposed to a pure/ethylated Ascorbic.! Is that it can be well-tolerated and a complimentary and effective acne treatment, Kao, J., Li J.... Anti-Oxidant, collagen-boosting, and salicylic acid, together, start by applying hyaluronic acid and salicylic can... Overexpression induced by retinoic acid through inhibition of EGFR/ERK in cultured human fibroblasts... Ray–Induced damage protection are also offered when antioxidants are able to reduce the production of free radical damage—the behind! N'T play nice recommend you put on benzoyl peroxide in the treatment of acne [ ]...